Endoscopic identification of Peyer’s patches of the terminal ileum in a patient with Crohn’s disease
Open Access
- 1 January 2004
- journal article
- case report
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 10 (18), 2767-2768
- https://doi.org/10.3748/wjg.v10.i18.2767
Abstract
We presented a 20-year-old patient with Crohn’s disease (CD). Colonoscopy revealed longitudinal ulceration in the terminal ileum and rectal aphtoid ulcers. After treatment with mesalamine and total parenteral nutrition, repeat colonoscopy revealed a granular elevated area in the terminal ileum, which appeared as an irregular dome-like elevation with irregularly arranged villi on magnifying endoscopy. Biopsy specimens taken from the region showed microgranulomas and lymphoid hyperplasia. Scanning electron microscopy revealed the presence of M cells, confirming that the area corresponded to Peyer’s patches. Peyer’s patches by magnifying endoscopy and electron microscopy may provide insights into the pathogenesis of CD.Keywords
This publication has 6 references indexed in Scilit:
- Distribution of Peyer's Patches in the Distal IleumInflammatory Bowel Diseases, 2002
- Microbiology of the intestinal lymph follicle: a clue to elucidate causative microbial agent(s) in Crohn's diseaseMedical Hypotheses, 1998
- The Role of Peyer's Patches in the Age-Related Incidence of Crohn's DiseaseJournal of Clinical Gastroenterology, 1997
- The significance of colonic mucosal lymphoid hyperplasia and aphthoid ulcers in crohn's diseaseClinical Radiology, 1996
- Pathogenesis of aphthoid ulcers in Crohn's disease: correlative findings by magnifying colonoscopy, electron microscopy, and immunohistochemistry.Gut, 1996
- Crohn's Disease (Regional Enteritis) of the Large Intestine and its Distinction from Ulcerative ColitisGut, 1960