Diabetic lung, an underrated complication from restrictive functional pattern to pulmonary hypertension
- 25 March 2019
- journal article
- editorial
- Published by Wiley in Diabetes/Metabolism Research and Reviews
- Vol. 35 (6), e3159
- https://doi.org/10.1002/dmrr.3159
Abstract
In patients with type 1 and type 2 diabetes mellitus (DM), respiratory function abnormalities have been reported with regard to lung volumes, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Indeed, the decrease in lung volumes and the impairment of diffusing capacity might have important clinical implications. Furthermore, there is an increasing evidence of a link between DM and pulmonary hypertension (PH) related to an involvement of the pulmonary vascular structures. These findings support the view of the lung as target organ in DM. In this paper we briefly describe the main derangements of the respiratory system in DM and the inherent mechanisms.Keywords
This publication has 31 references indexed in Scilit:
- The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low‐dose aspirin in patients with and without diabetesJournal of Thrombosis and Haemostasis, 2012
- Reduced respiratory muscle strength and endurance in type 2 diabetes mellitusDiabetes/Metabolism Research and Reviews, 2012
- Type 1 Diabetes-Induced Hyper-Responsiveness to 5-Hydroxytryptamine in Rat Pulmonary Arteries via Oxidative Stress and Induction of Cyclooxygenase-2Journal of Pharmacology and Experimental Therapeutics, 2011
- Unrecognized glucose intolerance is common in pulmonary arterial hypertensionThe Journal of Heart and Lung Transplantation, 2011
- The Pulmonary Circulation and Exercise Responses in the ElderlySeminars in Respiratory and Critical Care Medicine, 2010
- Updated Clinical Classification of Pulmonary HypertensionJournal of the American College of Cardiology, 2009
- Oxidant Stress Impairs In Vivo Reendothelialization Capacity of Endothelial Progenitor Cells From Patients With Type 2 Diabetes MellitusCirculation, 2007
- The diabetic lung: Relevance of alveolar microangiopathy for the use of inhaled insulinAmerican Journal Of Medicine, 2005
- Lung Function and Cardiovascular RiskCirculation, 2002
- Postural Variations of Pulmonary Diffusing Capacity in Insulin-Dependent Diabetes MellitusChest, 1996