Long non-coding RNAs and cancer: a new frontier of translational research?
Open Access
- 23 January 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 31 (43), 4577-4587
- https://doi.org/10.1038/onc.2011.621
Abstract
Tiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes, particularly those involved in disease, are still a matter of debate. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in cancer. We define lncRNAs and present a cancer-oriented list of lncRNAs, list some tools (for example, public databases) that classify lncRNAs or that scan genome spans of interest to find whether known lncRNAs reside there, and describe some of the functions of lncRNAs and the possible genetic mechanisms that underlie lncRNA expression changes in cancer, as well as current and potential future applications of lncRNA research in the treatment of cancer.Keywords
This publication has 151 references indexed in Scilit:
- YY1 Tethers Xist RNA to the Inactive X Nucleation CenterCell, 2011
- Expression and Function of a Large Non‐coding RNA Gene XIST in Human CancerWorld Journal of Surgery, 2011
- Long Noncoding RNAs with Enhancer-like Function in Human CellsCell, 2010
- A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 ResponseCell, 2010
- Natural Mutagenesis of Human Genomes by Endogenous RetrotransposonsCell, 2010
- Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4aMolecular Cell, 2010
- ConteXt of change—X inactivation and diseaseEMBO Molecular Medicine, 2009
- Altered Nuclear Retention of mRNAs Containing Inverted Repeats in Human Embryonic Stem Cells: Functional Role of a Nuclear Noncoding RNAMolecular Cell, 2009
- 3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNACell, 2008
- The relationship between non‐protein‐coding DNA and eukaryotic complexityBioEssays, 2007