Pathologic Findings Associated With Invasive EEG Monitoring for Medically Intractable Epilepsy
Open Access
- 1 October 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 138 (4), 506-510
- https://doi.org/10.1309/ajcpgsnl9vdvnjmx
Abstract
Invasive electroencephalography (EEG) monitoring is often needed for presurgical evaluation in patients with medically intractable epilepsy (MIE). This study retrospectively reviews the pathologic changes associated with EEG monitoring. Two hundred twenty-six patients who underwent invasive monitoring (53.5% males; mean age, 29.8 years) and 55 controls without EEG monitoring (52.7% males; mean age, 25.6 years) were evaluated. Median length of invasive EEG monitoring was 7.0 days. Compared with controls, patients who were monitored had more pathologic changes related to invasive EEG monitoring (n = 171 [75.7%] vs n = 12 [21.8%]; P < .0001) including meningeal or parenchymal chronic inflammation (n = 128 [56.4%] vs n = 11 [20.4%]; P < .0001) and acute contusion and/or acute/subacute infarct (n = 110 [48.5%] vs n = 0; P < .0001). Histologic evidence of pathologic changes typically associated with invasive monitoring and/or craniotomy occurred in 76% of our patients with invasive monitoring compared with 19% in patients without prior invasive EEG evaluation. The most common pathologic changes related to invasive monitoring were chronic inflammation and contusion/infarct.Keywords
This publication has 9 references indexed in Scilit:
- Identification of Pharmacoresistant EpilepsyNeurologic Clinics, 2009
- Intractable epilepsy: management and therapeutic alternativesThe Lancet Neurology, 2008
- Cognitive prognosis in chronic temporal lobe epilepsyAnnals of Neurology, 2006
- Defining Intractability: Comparisons among Published DefinitionsEpilepsia, 2006
- Diagnosis and treatment of mood disorders in persons with epilepsyCurrent Opinion in Neurology, 2005
- Terminology and classification of the cortical dysplasiasNeurology, 2004
- Diagnosis and staging of Rasmussen’s encephalitis by serial MRI and histopathologyNeurology, 2002
- Early Identification of Refractory EpilepsyNew England Journal of Medicine, 2000
- Patient-oriented outcome assessment after temporal lobectomy for refractory epilepsyNeurology, 1999