Hormone Replacement Therapy, Family History, and Breast Cancer Risk Among Postmenopausal Women
- 1 September 2009
- journal article
- breast cancer
- Published by Ovid Technologies (Wolters Kluwer Health) in Epidemiology
- Vol. 20 (5), 752-756
- https://doi.org/10.1097/ede.0b013e3181a71279
Abstract
Evidence is mixed regarding how familial predisposition to breast cancer affects the relation between hormone replacement therapy and risk of postmenopausal breast cancer. We investigated whether the risk difference for invasive breast cancer attributable to estrogen plus progesterone replacement therapy is greater among women with a first-degree family history of the disease. This study is a longitudinal follow-up of 16,608 postmenopausal women aged 50–79 years who were enrolled between 1993 and 2002 in the Women's Health Initiative randomized trial of estrogen plus progesterone replacement therapy versus placebo. Three hundred forty-nine cases of invasive breast cancer occurred during a mean follow-up period of 5.6 years. The invasive breast cancer risk difference attributable to the hormone therapy was 0.007 among women with first-degree family history and 0.005 among the others, resulting in a negligible interaction contrast (IC = 0.002; 95% confidence interval = −0.014 to 0.018). The interaction contrast restricted to estrogen-receptor-positive invasive breast cancers was also negligible (IC = −0.006; 95% CI = −0.021 to 0.008). Family history and estrogen plus progesterone replacement therapy have independent and noninteracting effects on the risk of invasive breast cancer among participants in the Women's Health Initiative randomized trial.Keywords
This publication has 26 references indexed in Scilit:
- Breast cancer risk associated with different HRT formulations: a register-based case-control studyBMC Women's Health, 2006
- Factors Modifying the Association Between Hormone-Replacement Therapy and Breast Cancer RiskEuropean Journal of Epidemiology, 2005
- Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal WomenJAMA, 2003
- Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled TrialJAMA, 2002
- Design of the Women’s Health Initiative Clinical Trial and Observational StudyControlled Clinical Trials, 1998
- Family History, Age, and Risk of Breast CancerJama-Journal Of The American Medical Association, 1993
- Hormone replacement therapy and risk of breast cancer: Results from epidemiologic studiesAmerican Journal of Obstetrics and Gynecology, 1993
- Heterogeneity of the Effect of Family History on Breast Cancer RiskEpidemiology, 1991
- Projecting Individualized Probabilities of Developing Breast Cancer for White Females Who Are Being Examined AnnuallyJNCI Journal of the National Cancer Institute, 1989
- The association of replacement estrogens with breast cancerInternational Journal of Cancer, 1986