Virulence factors of theMycobacterium tuberculosiscomplex
Top Cited Papers
Open Access
- 1 January 2013
- journal article
- review article
- Published by Informa UK Limited in Virulence
- Vol. 4 (1), 3-66
- https://doi.org/10.4161/viru.22329
Abstract
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world.Keywords
This publication has 483 references indexed in Scilit:
- Mycobacterium tuberculosis Inhibits Neutrophil Apoptosis, Leading to Delayed Activation of Naive CD4 T cellsCell Host & Microbe, 2012
- Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human MacrophagesCell Host & Microbe, 2011
- Lipids, apoptosis, and cross-presentation: links in the chain of host defense against Mycobacterium tuberculosisMicrobes and Infection, 2011
- Sulfolipid accumulation in Mycobacterium tuberculosis disrupted in the mce2 operonJournal of Microbiology, 2011
- Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosisEMBO Molecular Medicine, 2011
- Structural Insight into Serine Protease Rv3671c that Protects M. tuberculosis from Oxidative and Acidic StressStructure, 2010
- Mycobacterium tuberculosis MycP1 Protease Plays a Dual Role in Regulation of ESX-1 Secretion and VirulenceCell Host & Microbe, 2010
- Mycobacterium tuberculosis Prevents Inflammasome ActivationCell Host & Microbe, 2008
- M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid CellsCell, 2007
- The Heat Shock Response ofMycobacterium tuberculosis: Linking Gene Expression, Immunology and PathogenesisComparative and Functional Genomics, 2002