A barrier model for current flow in lipid bilayer membranes
- 1 December 1973
- journal article
- Published by Springer Science and Business Media LLC in The Journal of Membrane Biology
- Vol. 11 (1), 75-97
- https://doi.org/10.1007/bf01869814
Abstract
Theshape of the energy barrier inside thin, insulating membranes can be an important factor in determining the detailed behavior of transmembrane ionic flows. In particular, a model is developed in which the shape of the barrier is expected to have direct influence on such experimentally important membrane properties as: (a) the shape of the current-voltage relation; (b) the dependence of zero current conductivity on asymmetric concentrations; (c) the dependence of the rectification ratio on the concentration ratio. Current-voltage curves were measured for a wide range of symmetrical and asymmetrical concentrations in black lipid (phosphatidyl ethanolamine) films in the presence of nonactin and potassium. A single barrier shape was found to describe accurately the experimental results in terms of the model.Keywords
This publication has 15 references indexed in Scilit:
- The Rate Constants of Valinomycin-Mediated Ion Transport through Thin Lipid MembranesBiophysical Journal, 1971
- Space charge-limited conductance in lipid bilayer membranesThe Journal of Membrane Biology, 1970
- Surface Charge and the Conductance of Phospholipid MembranesProceedings of the National Academy of Sciences of the United States of America, 1970
- Kinetics of carrier-mediated ion transport across lipid bilayer membranesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1970
- Nonlinear Electrical Effects in Lipid Bilayer MembranesBiophysical Journal, 1969
- The Effect of Valinomycin on the Ionic Permeability of Thin Lipid MembranesThe Journal of general physiology, 1967
- Development of K+Na+ discrimination in experimental bimolecular lipid membranes by macrocyclic antibioticsBiochemical and Biophysical Research Communications, 1967
- Komplexe von Nonactin und Monactin mit Natrium‐, Kalium‐und Ammonium‐IonenHelvetica Chimica Acta, 1967
- The variation of capacitance and conductance of bimolecular lipid membranes with areaJournal of Theoretical Biology, 1965
- Reconstitution of Excitable Cell Membrane Structure in VitroCell Metabolism, 1962