Mucin expression profile in pancreatic cancer and the precursor lesions
- 29 May 2007
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Hepato-Biliary-Pancreatic Surgery
- Vol. 14 (3), 243-254
- https://doi.org/10.1007/s00534-006-1169-2
Abstract
In this review article, we demonstrate the mucin expression profile in normal tissue, invasive ductal carcinoma (IDC), two subtypes of intraductal papillary–mucinous neoplasm (IPMN dark cell type and IPMN clear cell type), pancreatic intraepithelial neoplasia (PanIN), and mucinous cystic neoplasm (MCN) of the pancreas. In MUC1, there are various glycoforms, such as poorly glycosylated MUC1, sialylated MUC1, and fully glycosylated MUC1. IDCs showed high expression of all the glycoforms of MUC1. IPMNs dark cell type showed no expression or low expression of all the glycoforms of MUC1. IPMNs clear cell type showed low expression of poorly glycosylated MUC1, but expression of sialylated MUC1 and fully glycosylated MUC1. Expression of MUC2 was negative in IDCs, high in IPMNs dark cell type and low in IPMNs clear cell type. MUC5AC was highly expressed in IDCs, IPMNs dark cell type, and IPMNs clear cell type. MUC6 expression was higher in IPMNs clear cell type than in IDCs and IPMNs dark cell type. Our recent study demonstrated that high expression of MUC4 in IDCs is correlated with a poor outcome for patients. In PanINs, expression of both MUC5AC and MUC6 are an early event, whereas up-regulation of MUC1 is a late event. MCNs do not look as if they will show a specific mucin expression profile according to the literature review.Keywords
This publication has 74 references indexed in Scilit:
- Expression Profiles of MUC Mucin Core Protein in the Intrahepatic Biliary System: Physiological Distribution and Pathological SignificanceACTA HISTOCHEMICA ET CYTOCHEMICA, 2005
- Classification of Pancreatic CancerPancreas, 2004
- Muc4/Sialomucin Complex, the Intramembrane ErbB2 Ligand, Translocates ErbB2 to the Apical Surface in Polarized Epithelial CellsJournal of Biological Chemistry, 2003
- HER-2 receptor expression, localization, and activation in colorectal cancer cell lines and human tumorsInternational Journal of Cancer, 2003
- Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27kip, but does not activate mitogen-activated kinase or protein kinaseB/Akt pathwaysOncogene, 2002
- MUC17, a Novel Membrane-Tethered MucinBiochemical and Biophysical Research Communications, 2002
- The role of p27kip1 protein expression on the biological behavior of intrahepatic cholangiocarcinomaHepatology, 2001
- Structural organization and classification of the human mucin genesFrontiers in Bioscience-Landmark, 2001
- MUC‐1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreasPathology International, 1998
- Human Mucin Genes Assigned to 11p15.5: Identification and Organization of a Cluster of GenesGenomics, 1996