The terminal nucleotides of retrovirus DNA are required for integration but not virus production
- 31 October 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 306 (5939), 155-160
- https://doi.org/10.1038/306155a0
Abstract
Deletion of specific nucleotides at either end of the long terminal repeat of the avian retrovirus, spleen necrosis virus, results in replication-competent but integration-defective virus. This result supports 2 conclusions: the 5-base pair terminal inverted repeats and 3-7 adjacent nucleotides are required for integration; integration of retrovirus DNA is not required for retrovirus gene expression.This publication has 65 references indexed in Scilit:
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