An integrated view of L‐selectin and trophinin function in human embryo implantation
Open Access
- 15 April 2008
- journal article
- review article
- Published by Wiley in Journal of Obstetrics and Gynaecology Research
- Vol. 34 (2), 129-136
- https://doi.org/10.1111/j.1447-0756.2008.00776.x
Abstract
Determining molecular mechanisms of human embryo implantation is an extremely challenging task due to the limitation of materials and significant differences underlying this process among mammalian species. Recently, L‐selectin and its ligand carbohydrate have been proposed as a system that mediates initial adhesion of human blastocysts to the uterine epithelia. We have also identified trophinin as a unique apical cell adhesion molecule potentially involved in the initial adhesion of trophectoderm of the human blastocyst to endometrial surface epithelia. In the mouse, the binding between ErbB4 on the blastocyst and heparin‐binding epidermal growth factor‐like growth factor on the endometrial surface enables the initial step of the blastocyst implantation. The evidence suggests that L‐selectin and trophinin are included in human embryo implantation. This review summarizes findings relevant to the functions of L‐selectin and trophinin in human embryo implantation, and proposes a model that reconciles these cell adhesion mechanisms.Keywords
This publication has 93 references indexed in Scilit:
- Induction of trophinin in human endometrial surface epithelia by CGβ and IL‐1βFEBS Letters, 2007
- Maternal heparin-binding-EGF deficiency limits pregnancy success in miceProceedings of the National Academy of Sciences of the United States of America, 2007
- Trophoblast cell activation by trophinin ligation is implicated in human embryo implantationProceedings of the National Academy of Sciences of the United States of America, 2007
- N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venulesNature Immunology, 2005
- Core 2 Branching β1,6-N-Acetylglucosaminyltransferase and High Endothelial Venule-restricted Sulfotransferase Collaboratively Control Lymphocyte HomingPublished by Elsevier BV ,2004
- The cell biological basis of human implantationBest Practice & Research Clinical Obstetrics & Gynaecology, 2000
- Dynamics of Uterine Glycoconjugate Expression and FunctionSeminars in Reproductive Medicine, 1999
- Implanting mouse embryo stain with a LNF-I bearing fluorescent probe at their mural trophectodermal sideBiochemical and Biophysical Research Communications, 1991
- Trophoblastic differentiation of human teratocarcinoma cell line HT-HDevelopmental Biology, 1986
- Murine embryonic antigen (SSEA-1) is expressed on human cells and structurally related human blood group antigen I is expressed on mouse embryosDevelopmental Biology, 1982