Note: Integration of trapped ion mobility spectrometry with mass spectrometry
- 1 December 2011
- journal article
- research article
- Published by AIP Publishing in Review of Scientific Instruments
- Vol. 82 (12), 126106
- https://doi.org/10.1063/1.3665933
Abstract
The integration of a trapped ion mobilityspectrometer (TIMS) with a mass spectrometer(MS) for complementary fast, gas-phase mobility separation prior to mass analysis (TIMS-MS) is described. The ion transmission and mobility separation are discussed as a function of the ion source condition, bath gas velocity, analysis scan speed, RF ion confinement, and downstream ion optical conditions. TIMS mobility resolution depends on the analysis scan speed and the bath gas velocity, with the unique advantage that the IMS separation can be easily tuned from high speed (∼25 ms) for rapid analysis to slower scans for higher mobility resolution (R > 80).Keywords
Funding Information
- National Institutes of Health (1K99RR030188-01, 2010&2011)
This publication has 1 reference indexed in Scilit:
- Gas-phase separation using a trapped ion mobility spectrometerInternational Journal for Ion Mobility Spectrometry, 2011