Epidemiology of Gastrointestinal Stromal Tumors in a Defined Canadian Health Region: A Population-Based Study
- 2 April 2008
- journal article
- Published by SAGE Publications in International Journal of Surgical Pathology
- Vol. 16 (3), 241-250
- https://doi.org/10.1177/1066896907306967
Abstract
The aim of this study was to determine the incidence and the clinical and pathological features of gastrointestinal stromal tumors within a nonselected, well-defined Canadian Health Region. A population-based cohort study of all adult patients diagnosed with gastrointestinal stromal tumors was conducted in the Calgary Health Region from April 2000 to March 2004. All charts and pathological specimens were reviewed for clinical, histological, and antigenic features. The age-adjusted and gender-adjusted annual incidence rate was 0.91/105 person-years. There was a trend for increased incidence with routine use of CD117. The only identified risk was advancing age (age ≥50; rate ratio = 4.6; P = .0006). All samples were positive for CD117. At presentation, 19% were at intermediate and 19% were at high risk of becoming malignant, with 14% being overtly metastatic. This is the first North American study to define the incidence and the clinical and pathologic features of gastrointestinal stromal tumors based on current diagnostic criteria.Keywords
This publication has 31 references indexed in Scilit:
- Current Incidence and Outcomes of Gastrointestinal Mesenchymal Tumors Including Gastrointestinal Stromal TumorsJournal of the American College of Surgeons, 2006
- Incidence of gastrointestinal stromal tumours is underestimated: Results of a nation-wide studyEuropean Journal of Cancer, 2005
- Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate eraCancer, 2005
- Surgery and Imatinib in the Management of GIST: Emerging Approaches to Adjuvant and Neoadjuvant TherapyAnnals of Surgical Oncology, 2004
- Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumoursBritish Journal of Surgery, 2003
- Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal TumorsThe New England Journal of Medicine, 2002
- Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal TumorsScience, 1998
- W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activityNature, 1995
- Gastric stromal tumors Reappraisal of histogenesisThe American Journal of Surgical Pathology, 1983
- The Triad of Gastric Leiomyosarcoma, Functioning Extra-Adrenal Paraganglioma and Pulmonary ChondromaThe New England Journal of Medicine, 1977