Understanding the Clinical Heterogeneity of Major Depression Using Family Data
- 1 May 1986
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 43 (5), 430-4
- https://doi.org/10.1001/archpsyc.1986.01800050028003
Abstract
For major depression, putative subgroups have been defined by age at onset, clinical severity, symptom patterns, or the presence of other disorders (comorbidity), yet the high degree of overlap in clinical presentation makes it difficult to determine which combination of criteria for defining subgroups best predicts familial aggregation. In dealing with this overlap, we found that only early age at onset, or major depression with an anxiety disorder or secondary alcoholism, were independently related to increased risk of major depression in relatives. Once the effects of these proband factors had been taken into account, endogenous, delusional, melancholic, or autonomous symptom patterns, recurrent depression, history of hospitalization, and suicidal ideation or attempts in probands were not associated with increased risk of major depression in relatives.Keywords
This publication has 13 references indexed in Scilit:
- Validity of RDC and DSM-IIIArchives of General Psychiatry, 1985
- Familial Transmission of Depression and AlcoholismArchives of General Psychiatry, 1985
- The Polydiagnostic Approach in Research on DepressionPublished by Springer Science and Business Media LLC ,1985
- Anxiety disorders and depression: contradictions between family study data and DSM-III conventionsAmerican Journal of Psychiatry, 1983
- Variability in Rates of Affective Disorders in Relatives of Depressed and Normal ProbandsArchives of General Psychiatry, 1982
- Best Estimate of Lifetime Psychiatric DiagnosisArchives of General Psychiatry, 1982
- A Multivariate Analysis of Prognostic Factors for Melanoma Patients with Lesions > 3.65 mm in Thickness The Importance of Revealing Alternative Cox Models*Annals of Surgery, 1982
- Situational Depression: Validity of the ConceptThe British Journal of Psychiatry, 1981
- Primary Affective Disorder Criteria and the Endogenous-Reactive DistinctionArchives of General Psychiatry, 1980
- IS A FAMILIAL DEFINITION OF DEPRESSION BOTH FEASIBLE AND VALID?The Journal of Nervous and Mental Disease, 1978