Immediate noninvasive ventilation may improve mortality in patients with hepatopulmonary syndrome after liver transplantation
- 28 January 2011
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Liver Transplantation
- Vol. 17 (2), 144-148
- https://doi.org/10.1002/lt.22207
Abstract
Hepatopulmonary syndrome (HPS) is defined as hypoxemia induced by intrapulmonary vascular dilations associated with liver disease. Although liver transplantation (LT) is the only effective therapy established for severe HPS, patients with a partial pressure of arterial oxygen (PaO2) less than 60 mm Hg have a poor prognosis. We treated a 4‐year‐old boy with HPS whose preoperative PaO2 level was 48.8 mm Hg. After LT, he had persistent severe hypoxemia, although he was receiving high‐flow oxygen. Noninvasive ventilation (NIV) was introduced, and his respiratory insufficiency promptly improved. Therefore, NIV therapy immediately after extubation following transplantation was administered to the next 4 consecutive HPS patients whose preoperative PaO2 was less than 60 mm Hg. The NIV treatment of these 5 patients could have been responsible for preventing severe postoperative complications as well as reintubation and hospital death. NIV therapy for both pediatric and adult patients with severe HPS immediately after extubation might protect them from severe hypoxemia after transplantation and from complications necessitating reintubation and might improve their prognosis. Liver Transpl 17:144–148, 2011. © 2011 AASLDKeywords
Funding Information
- Japanese Ministry of Education (20590921, 22590860)
- Respiratory Failure Research Group
- Health Sciences Research
- Comprehensive Research on Life-Style Related Diseases Including Cardiovascular Diseases and Diabetes Mellitus
- Japanese Ministry of Health, Labor, and Welfare
- Japan Vascular Disease Research Foundation
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