Microbiological surveillance and parenteral antibiotic use in a critical care unit
Open Access
- 1 January 2000
- journal article
- research article
- Published by Hindawi Limited in Canadian Journal of Infectious Diseases
- Vol. 11 (2), 107-111
- https://doi.org/10.1155/2000/672340
Abstract
OBJECTIVE: To evaluate parenteral antibiotic utilization and bacterial resistance patterns in a critical care unit (CrCU).DESIGN: Descriptive, prospective audit of infection site, culture and antimicrobial susceptibility test results, parenteral antibiotic usage and duration, total antibiotic acquisition costs, and length of stay.SETTING: A 17-bed medical-surgical CrCU in a tertiary care teaching hospital in Metropolitan Toronto.PATIENTS: Two hundred and fifty-eight patients admitted to the CrCU between May 1995 and April 1996 who received antimicrobial therapy.RESULTS: The most frequently prescribed antibiotics were cefazolin (47%, 1098 g), gentamicin (33%,141 g) and ceftriaxone (20%, 255 g). The most common indications for antimicrobial therapy included surgical prophylaxis (34%) and pneumonia (35%). The following organisms were isolated from patients treated with antibiotics:Staphylococcus aureus(26%),Pseudomonas aeruginosa(13%), enterococci (12%),Haemophilus influenzae(11%),Escherichia coli(11%),Enterobacter cloacae(8%) and other Gram-negative bacilli (19%). Only 9% of Gram-negative bacilli were resistant to aminoglycosides, 3% were resistant to ciprofloxacin and no extended-spectrum beta-lactamases or imipenem-resistance were detected. No vancomycin-resistant enterococci and only two methicillin-resistantStaphylococcus aureusisolates were identified.CONCLUSIONS: Antibiotic use during the audit appeared appropriate for the specific clinical indications. Low levels of bacterial resistance were detected during the audit.Keywords
This publication has 13 references indexed in Scilit:
- Antimicrobial use and resistance in eight US hospitals: complexities of analysis and modeling. Intensive Care Antimicrobial Resistance Epidemiology Project and National Nosocomial Infections Surveillance System Hospitals.1998
- Antimicrobial Resistance in Isolates from Inpatients and Outpatients in the United States: Increasing Importance of the Intensive Care UnitClinical Infectious Diseases, 1997
- Incidence and Susceptibility of Aerobic Gram-Negative Bacilli from 20 Canadian Intensive Care Units: 1989–1993Canadian Journal of Infectious Diseases, 1996
- The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee.1995
- Focused Microbiological Surveillance and Gram-Negative Beta-Lactamase-Mediated Resistance in an Intensive Care UnitInfection Control & Hospital Epidemiology, 1995
- Focused microbiological surveillance by specific hospital unit as a sensitive means of defining antimicrobial resistance problemsDiagnostic Microbiology and Infectious Disease, 1992
- Enterobacter Bacteremia: Clinical Features and Emergence of Antibiotic Resistance during TherapyAnnals of Internal Medicine, 1991
- Inducible -Lactamases: Clinical and Epidemiologic Implications for Use of Newer CephalosporinsClinical Infectious Diseases, 1988
- Health and Economic Impacts of Antimicrobial ResistanceClinical Infectious Diseases, 1987
- Drug Use in a Surgical Intensive Care UnitDrug Intelligence & Clinical Pharmacy, 1986