The Association of Alanine Transaminase With Aging, Frailty, and Mortality
Open Access
- 24 May 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
- Vol. 65A (7), 712-717
- https://doi.org/10.1093/gerona/glq082
Abstract
The relationships between blood tests of liver function and injury (alanine transaminase [ALT], gamma-glutamyl transferase, bilirubin, and albumin) with age, frailty, and survival were investigated in 1,673 community-dwelling men aged 70 years or older. ALT was lower in older participants. Those participants with ALT below the median at baseline had reduced survival (hazard ratio 2.10, 95% confidence interval [CI] 1.53–2.87) up to 4.9 years. Older age, frailty, low albumin, low body mass index, and alcohol abstinence also were associated with reduced survival, with age and frailty being the most powerful predictors. Low ALT was associated with frailty (odds ratio 3.54, 95% CI 2.45–5.11), and the relationship between ALT and survival disappeared once frailty and age were included in the survival analysis. Low ALT activity is a predictor of reduced survival; however, this seems to be mediated by its association with frailty and increasing age. ALT has potential value as a novel biomarker of aging.Keywords
This publication has 25 references indexed in Scilit:
- Alanine aminotransferase, γ‐glutamyltransferase (GGT) and all‐cause mortality: results from a population‐based Danish twins study alanine aminotransferase, GGT and mortality in elderly twinsLiver International, 2009
- Prevalence of Frailty in Middle-Aged and Older Community-Dwelling Europeans Living in 10 CountriesThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2009
- Pain, frailty and comorbidity on older men: The CHAMP studyPain, 2008
- Biomarkers of Inflammation and Malnutrition Associated with Early Death in Healthy Elderly PeopleJournal of the American Geriatrics Society, 2008
- The current state of serum biomarkers of hepatotoxicityToxicology, 2008
- Obesity in Old AgeFrontiers of Hormone Research, 2008
- Lower Levels of Serum Albumin and Total Cholesterol Associated with Decline in Activities of Daily Living and Excess Mortality in a 12‐Year Cohort Study of Elderly JapaneseJournal of the American Geriatrics Society, 2007
- Low Alanine Aminotransferase Activity in Older People Is Associated with Greater Long‐Term MortalityJournal of the American Geriatrics Society, 2006
- Health consequences of obesity in the elderly: a review of four unresolved questionsInternational Journal of Obesity, 2005
- Lower levels of serum albumin and total cholesterol and future decline in functional performance in older persons: the Longitudinal Aging Study AmsterdamAge and Ageing, 2004