Neural stem cells and epilepsy: functional roles and disease-in-a-dish models
- 22 August 2017
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 371 (1), 47-54
- https://doi.org/10.1007/s00441-017-2675-z
Abstract
Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although current therapies exist to control the number and severity of clinical seizures, there are no pharmacological cures or disease-modifying treatments available. Use of transgenic mouse models has allowed an understanding of neural stem cells in their relation to epileptogenesis in mesial temporal lobe epilepsy. Further, with the significant discovery of factors necessary to reprogram adult somatic cell types into pluripotent stem cells, it has become possible to study monogenic epilepsy-in-a-dish using patient-derived neurons. This discovery along with some of the newest technological advances in recapitulating brain development in a dish has brought us closer than ever to a platform in which to study and understand the mechanisms of this disease. These technologies will be critical in understanding the mechanism of epileptogenesis and ultimately lead to improved therapies and precision medicine for patients with epilepsy.Keywords
Funding Information
- National Center for Advancing Translational Sciences (UL1TR001105)
- NIH (R01NS093992)
- Texas Institute for Brain Injury and Repair, University of Texas Southwestern Medical Center
- U.S. Department of Defense (W81XWH-15-1)
- American Heart Association (15GRNT25750034)
This publication has 59 references indexed in Scilit:
- Dravet syndrome patient‐derived neurons suggest a novel epilepsy mechanismAnnals of Neurology, 2013
- Introduction to Institute of Medicine ReportEpilepsy Currents, 2012
- Depression, stress, epilepsy and adult neurogenesisExperimental Neurology, 2012
- Sodium channel SCN1A and epilepsy: Mutations and mechanismsEpilepsia, 2010
- New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?Nature Reviews Neuroscience, 2010
- Radiation of the Rat Brain Suppresses Seizure‐Induced Neurogenesis and Transiently Enhances Excitability during Kindling AcquisitionEpilepsia, 2007
- Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticusNeurobiology of Disease, 2006
- Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell, 2006
- Enhanced Excitability Induced by Ionizing Radiation in the Kindled RatExperimental Neurology, 2001
- Initial sequencing and analysis of the human genomeNature, 2001