Cellular Effects of Helium in Different Organs
- 1 June 2010
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesiology
- Vol. 112 (6), 1503-1510
- https://doi.org/10.1097/aln.0b013e3181d9cb5e
Abstract
Experimental research in cardiac and neuronal tissue has shown that besides volatile anesthetics and xenon, the nonanesthetic noble gas helium also reduces ischemia-reperfusion damage. Even though the distinct mechanisms of helium-induced organ protection are not completely unraveled, several signaling pathways have been identified. Beside the protective effects on heart and brain that are mainly obtained by different pre- and postconditioning protocols, helium also exerts effects in the lungs, the immune system, and the blood vessels. Obviously, this noble gas is biochemically not inert and exerts biologic effects, although until today the question remains open on how these changes are mediated. Because of its favorable characteristics and the lack of hemodynamic side effects, helium is suitable for use also in critically ill patients. This review covers the cellular effects of helium, which may lead to new clinical strategies of tissue salvage in ischemia-reperfusion situations, both within and outside the perioperative setting.Keywords
This publication has 64 references indexed in Scilit:
- Preconditioning and postconditioning: Underlying mechanisms and clinical applicationAtherosclerosis, 2009
- Post-Ischemic Helium Provides Neuroprotection in Rats Subjected to Middle Cerebral Artery Occlusion-Induced Ischemia by Producing HypothermiaJournal of Cerebral Blood Flow & Metabolism, 2009
- The uses of helium and xenon in current clinical practiceAnaesthesia, 2008
- Inhalational Anaesthetics and CardioprotectionPublished by Springer Science and Business Media LLC ,2008
- Warum 37°C?Der Anaesthesist, 2007
- The effect of anaesthetics on the myocardium - new insights into myocardial protectionEuropean Journal of Anaesthesiology, 2005
- Desflurane Preconditioning Induces Time-dependent Activation of Protein Kinase C Epsilon and Extracellular Signal-regulated Kinase 1 and 2 in the Rat Heart In VivoAnesthesiology, 2004
- How has molecular pharmacology contributed to our understanding of the mechanism(s) of general anesthesia?Pharmacology & Therapeutics, 1996
- Pressure Reversal of AnaesthesiaNature, 1971
- The Anesthetic Properties of Xenon in Animals and Human Beings, with Additional Observations on KryptonScience, 1951