Bacterial Chromosome Organization and Segregation
Open Access
- 20 January 2010
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 2 (2), a000349
- https://doi.org/10.1101/cshperspect.a000349
Abstract
Bacterial chromosomes are generally ∼1000 times longer than the cells in which they reside, and concurrent replication, segregation, and transcription/translation of this crowded mass of DNA poses a challenging organizational problem. Recent advances in cell-imaging technology with subdiffraction resolution have revealed that the bacterial nucleoid is reliably oriented and highly organized within the cell. Such organization is transmitted from one generation to the next by progressive segregation of daughter chromosomes and anchoring of DNA to the cell envelope. Active segregation by a mitotic machinery appears to be common; however, the mode of chromosome segregation varies significantly from species to species.Keywords
This publication has 97 references indexed in Scilit:
- Caulobacter requires a dedicated mechanism to initiate chromosome segregationProceedings of the National Academy of Sciences, 2008
- A Self-Associating Protein Critical for Chromosome Attachment, Division, and Polar Organization in CaulobacterCell, 2008
- A Polymeric Protein Anchors the Chromosomal Origin/ParB Complex at a Bacterial Cell PoleCell, 2008
- Sequence-directed DNA export guides chromosome translocation during sporulation in Bacillus subtilisNature Structural & Molecular Biology, 2008
- The ATPase SpoIIIE Transports DNA across Fused Septal Membranes during Sporulation in Bacillus subtilisCell, 2007
- Soj (ParA) DNA binding is mediated by conserved arginines and is essential for plasmid segregationProceedings of the National Academy of Sciences, 2007
- par genes and the pathology of chromosome loss in Vibrio choleraeProceedings of the National Academy of Sciences of the United States of America, 2007
- A dynamic, mitotic-like mechanism for bacterial chromosome segregationGenes & Development, 2006
- Entropy-driven spatial organization of highly confined polymers: Lessons for the bacterial chromosomeProceedings of the National Academy of Sciences, 2006
- The twoEscherichia colichromosome arms locate to separate cell halvesGenes & Development, 2006