Highly Regioselective Synthesis of Substituted Pyrroles Utilizing Low-Valent Titanium Reagent

Abstract

A short and efficient synthesis of substituted pyrroles was accomplished in good yields via the novel coupling cyclization reaction of 1,3-diketones with imines promoted by low-valent titanium reagent. High regioselectivity was achieved and the structures of two of the products were confirmed by X-ray diffraction studies.