MAMMALIAN SELENIUM-CONTAINING PROTEINS
- 1 July 2001
- journal article
- review article
- Published by Annual Reviews in Annual Review of Nutrition
- Vol. 21 (1), 453-473
- https://doi.org/10.1146/annurev.nutr.21.1.453
Abstract
▪ Abstract Mammalian selenium-containing proteins can be divided into three groups: proteins containing nonspecifically incorporated selenium, specific selenium-binding proteins, and specific selenocysteine-containing selenoproteins. Selenoproteins with known functions identified so far include five glutathione peroxidases, two deiodinases, several thioredoxin reductases, and selenophosphate synthetase 2. Alternative splicing leads to a greater variety of selenoproteins, as was shown in the cases of a specific sperm nuclei glutathione peroxidase and some thioredoxin reductases. Selenoprotein P, selenoprotein W, a 15-kDa selenoprotein, an 18-kDa selenoprotein, and several selenoproteins identified in silico from nucleotide sequence databases were found to contain selenocysteine but their functions are not known. Gel electrophoretic separation of tissue samples from rats labeled in vivo with 75Se showed the existence of further selenium-containing proteins.Keywords
This publication has 83 references indexed in Scilit:
- Import into Mitochondria of Phospholipid Hydroperoxide Glutathione Peroxidase Requires a Leader SequenceBiochemical and Biophysical Research Communications, 1996
- Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supplyFEBS Letters, 1996
- Knowing when not to stop: selenocysteine incorporation in eukaryotesTrends in Biochemical Sciences, 1996
- Rat Phospholipid-hydroperoxide Glutathione PeroxidaseOnline Journal of Public Health Informatics, 1995
- Cloning and sequencing of a human thioredoxin reductaseFEBS Letters, 1995
- Identification of type I iodothyronine 5′-deiodinase as a selenoenzymeBiochemical and Biophysical Research Communications, 1990
- A selenocysteine-containing selenium-transport protein in rat plasmaBiochimica et Biophysica Acta (BBA) - General Subjects, 1982
- Glutathione peroxidase: A selenoenzymeFEBS Letters, 1973
- SELENIUM AS AN INTEGRAL PART OF FACTOR 3 AGAINST DIETARY NECROTIC LIVER DEGENERATIONJournal of the American Chemical Society, 1957
- Der Nachweis des Selens im Knochen- und Zahngewebe.Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1916