Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses
- 6 September 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (24), 4727-4733
- https://doi.org/10.1016/j.febslet.2007.08.070
Abstract
Presynaptic nerve terminals contain scaffolding proteins that orchestrate neurotransmitter release at active zones. Here we describe mover, a yet unknown non-transmembrane protein that is targeted to presynaptic terminals when overexpressed in cultured neurons. Confocal immunomicroscopy revealed that mover colocalizes with presynaptic markers in the calyx of Held. In the hippocampus, mover localizes to mossy fibre terminals, but is absent from inhibitory nerve terminals. By contrast, mover localizes to inhibitory terminals throughout the cerebellar cortex. Our results suggest that mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminalsKeywords
This publication has 13 references indexed in Scilit:
- Molecular Dynamics of a Presynaptic Active Zone Protein Studied in Munc13-1–Enhanced Yellow Fluorescent Protein Knock-In Mutant MiceJournal of Neuroscience, 2006
- SNAREs — engines for membrane fusionNature Reviews Molecular Cell Biology, 2006
- Molecular organization of the presynaptic active zoneCell and tissue research, 2006
- Different Presynaptic Roles of Synapsins at Excitatory and Inhibitory SynapsesJournal of Neuroscience, 2004
- THE SYNAPTIC VESICLE CYCLEAnnual Review of Neuroscience, 2004
- RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zoneNature, 2002
- The Dynamics of SAP90/PSD-95 Recruitment to New Synaptic JunctionsMolecular and Cellular Neuroscience, 2001
- The presynaptic cytomatrix of brain synapsesCellular and Molecular Life Sciences, 2001
- Axonal Membrane Proteins Are Transported in Distinct Carriers: A Two-Color Video Microscopy Study in Cultured Hippocampal NeuronsMolecular Biology of the Cell, 2000
- Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.The Journal of cell biology, 1983