Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins
- 3 October 2007
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 102 (4), 829-839
- https://doi.org/10.1002/jcb.21509
Abstract
This review will highlight the significance of three critical pathways in developmental biology and our emerging understanding of their roles in regulating tumor metastasis: Bone morphogenic protein (BMP), Notch and Sonic hedgehog (SHH). We will discuss parallels between their known roles in development and how these processes can be used by tumor cells to create microenvironments that enhance tumor metastasis. That tumor cells usurp pathways critical to the developing embryo is not surprising, as many of the normal developmental programs include processes that are also seen during tumor progression to a metastatic phenotype, including epithelial to mesenchymal transition (EMT), tissue specific morphogenesis, cellular motility and invasion. BMPs are involved in EMT, contribute to tissue specific morphogenesis, and are expressed in highly‐metastatic tumor cells. BMPs have also been hypothesized to have a role in the establishment of a pre‐neoplastic niche. Notch and SHH facilitate neovascularization, angiogenesis, EMT and can contribute to the maintenance of highly‐metastatic tumor stem cells. J. Cell. Biochem. 102: 829–839, 2007.Keywords
This publication has 71 references indexed in Scilit:
- Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid CancersCancer Research, 2007
- BMP-4 treatment of C3H10T1/2 stem cells blocks expression of MMP-3 and MMP-13Biochemical and Biophysical Research Communications, 2007
- Stem Cells Signal to the Niche through the Notch Pathway in the Drosophila OvaryCurrent Biology, 2006
- Unique and complimentary activities of the Gli transcription factors in Hedgehog signalingExperimental Cell Research, 2006
- Vertebrate Smoothened functions at the primary ciliumNature, 2005
- Hedgehog signaling regulates expansion of pancreatic epithelial cellsDevelopmental Biology, 2005
- BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3Cell, 2003
- A role for Smad6 in development and homeostasis of the cardiovascular systemNature Genetics, 2000
- Notch Signaling: Cell Fate Control and Signal Integration in DevelopmentScience, 1999
- Sonic hedgehog signaling by the Patched–Smoothened receptor complexCurrent Biology, 1999