Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity
Open Access
- 2 January 2014
- journal article
- review article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2014, 1-8
- https://doi.org/10.1155/2014/840547
Abstract
Neurotoxicity is a term used to describe neurophysiological changes caused by exposure to toxic agents. Such exposure can result in neurocognitive symptoms and/or psychiatric disturbances. Common toxic agents include heavy metals, drugs, organophosphates, bacterial, and animal neurotoxins. Among heavy metal exposures, lead exposure is one of the most common exposures that can lead to significant neuropsychological and functional decline in humans. In this review, neurotoxic lead exposure's pathophysiology, etiology, and epidemiology are explored. In addition, commonly associated neuropsychological difficulties in intelligence, memory, executive functioning, attention, processing speed, language, visuospatial skills, motor skills, and affect/mood are explored.Keywords
This publication has 77 references indexed in Scilit:
- Neuropsychological function in children with blood lead levels μg/dLNeuroToxicology, 2007
- Reversible neurobehavioral performance with reductions in blood lead levels–A prospective study on lead workersNeurotoxicology and Teratology, 2005
- The Effect of Chelation Therapy with Succimer on Neuropsychological Development in Children Exposed to LeadThe New England Journal of Medicine, 2001
- Bone Lead Levels and Language Processing PerformanceDevelopmental Neuropsychology, 2000
- Independent effects of lead exposure and iron deficiency anemia on developmental outcome at age 2 yearsThe Journal of Pediatrics, 1992
- U‐Shaped dose‐response curves: Their occurrence and implications for risk assessmentJournal of Toxicology and Environmental Health, 1990
- The Long-Term Effects of Exposure to Low Doses of Lead in ChildhoodThe New England Journal of Medicine, 1990
- Port Pirie Cohort Study: Environmental Exposure to Lead and Children's Abilities at the Age of Four YearsThe New England Journal of Medicine, 1988
- Longitudinal Analyses of Prenatal and Postnatal Lead Exposure and Early Cognitive DevelopmentThe New England Journal of Medicine, 1987
- Encephalopthy due to inorganic lead exposure in an adult.Japanese Journal of Medicine, 1987