Activated omentum becomes rich in factors that promote healing and tissue regeneration
- 14 February 2007
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 328 (3), 487-497
- https://doi.org/10.1007/s00441-006-0356-4
Abstract
In order to study the mechanism by which an omental pedicle promotes healing when applied to an injured site, we injected a foreign body into the abdominal cavity to activate the omentum. One week after the injection, we isolated the omentum and measured blood vessel density, blood content, growth and angiogenesis factors (VEGF and others), chemotactic factors (SDF-1α), and progenitor cells (CXCR-4, WT-1). We found that the native omentum, which consisted mostly of adipose tissue, expanded the mass of its non-adipose part (milky spots) 15– to 20-fold. VEGF and other growth factors increased by two– to four-fold, blood vessel density by three-fold, and blood content by two-fold. The activated omentum also showed increases in SDF-1α, CXCR-4, and WT-1 cells (factors and cells positively associated with tissue regeneration). Thus, we propose that an omentum activated by a foreign body (or by injury) greatly expands its milky-spot tissue and becomes rich in growth factors and progenitor cells that facilitate the healing and regeneration of injured tissue.Keywords
This publication has 29 references indexed in Scilit:
- Antagonism of vascular endothelial growth factor results in microvessel attrition and disorganization of wound tissueJournal of Laboratory and Clinical Medicine, 2005
- The evolution of omentum transposition: from lymphedema to spinal cord, stroke and Alzheimer's diseaseNeurological Research, 2004
- Renal Organogenesis from Transplanted Metanephric PrimordiaJournal of the American Society of Nephrology, 2004
- SDF-1α/CXCR4: A Mechanism for Hepatic Oval Cell Activation and Bone Marrow Stem Cell Recruitment to the Injured Liver of RatsCloning and Stem Cells, 2002
- Life, Sex, and WT1 Isoforms— Three Amino Acids Can Make All the DifferenceCell, 2001
- Prospective study of omental transposition in patients with chronic spinal injuryJournal of Neurology, Neurosurgery & Psychiatry, 2001
- Omental transposition in chronic spinal cord injurySpinal Cord, 1996
- Perforation of a Meckelʼs Diverticulum Caused by Ingestion of a CoinSouthern Medical Journal, 1994
- Axonal regeneration after spinal cord transection and reconstructionBrain Research, 1992
- Some uses of undetached omentum in surgeryThe American Journal of Surgery, 1948