ClinicalCodes: An Online Clinical Codes Repository to Improve the Validity and Reproducibility of Research Using Electronic Medical Records
Open Access
- 18 June 2014
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 9 (6), e99825
- https://doi.org/10.1371/journal.pone.0099825
Abstract
Lists of clinical codes are the foundation for research undertaken using electronic medical records (EMRs). If clinical code lists are not available, reviewers are unable to determine the validity of research, full study replication is impossible, researchers are unable to make effective comparisons between studies, and the construction of new code lists is subject to much duplication of effort. Despite this, the publication of clinical codes is rarely if ever a requirement for obtaining grants, validating protocols, or publishing research. In a representative sample of 450 EMR primary research articles indexed on PubMed, we found that only 19 (5.1%) were accompanied by a full set of published clinical codes and 32 (8.6%) stated that code lists were available on request. To help address these problems, we have built an online repository where researchers using EMRs can upload and download lists of clinical codes. The repository will enable clinical researchers to better validate EMR studies, build on previous code lists and compare disease definitions across studies. It will also assist health informaticians in replicating database studies, tracking changes in disease definitions or clinical coding practice through time and sharing clinical code information across platforms and data sources as research objects.Keywords
This publication has 28 references indexed in Scilit:
- Making Research Data Repositories Visible: The re3data.org RegistryPLOS ONE, 2013
- Toward Reproducible Computational Research: An Empirical Analysis of Data and Code Policy Adoption by JournalsPLOS ONE, 2013
- Optimising Use of Electronic Health Records to Describe the Presentation of Rheumatoid Arthritis in Primary Care: A Strategy for Developing Code ListsPLOS ONE, 2013
- Setting the RECORD straight: developing a guideline for the REporting of studies Conducted using Observational Routinely collected DataClinical Epidemiology, 2013
- Shining Light into Black BoxesScience, 2012
- Coding, Recording and Incidence of Different Forms of Coronary Heart Disease in Primary CarePLOS ONE, 2012
- Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes FrameworkBMJ, 2011
- What does validation of cases in electronic record databases mean? The potential contribution of free textPharmacoepidemiology and Drug Safety, 2011
- Validation and validity of diagnoses in the General Practice Research Database: a systematic reviewBritish Journal of Clinical Pharmacology, 2009
- Selection of Medical Diagnostic Codes for Analysis of Electronic Patient Records. Application to Stroke in a Primary Care DatabasePLOS ONE, 2009