Pharmaceutical interventions for obesity: a public health perspective
- 20 April 2011
- journal article
- review article
- Published by Wiley in Diabetes, Obesity and Metabolism
- Vol. 13 (6), 490-497
- https://doi.org/10.1111/j.1463-1326.2010.01353.x
Abstract
The prevalence of obesity, a major risk factor for many chronic diseases, has risen in most developed countries over the past several decades. The economic burden for both public and private health care systems is substantial. Although certain non-pharmaceutical interventions have been proven efficacious in specific populations, the lack of scalability has caused many of these programmes to fail in sustainably decreasing the percent of patients who are overweight or obese. The benefits of other interventions, such as pharmaceutical agents, medical devices and surgery, should therefore be carefully considered: this article focuses on the first of these strategies. Various pharmaceutical products have been plagued with safety concerns or patient non-adherence because of unpleasant side effects. Therefore, the need for additional antiobesity drugs that are both safe and effective is considerable. This article discusses the regulatory landscape for the development of new antiobesity compounds in the United States and Europe and considers the ramifications of greater or lesser regulatory burdens.Keywords
This publication has 12 references indexed in Scilit:
- Size-Dependent Phase Diagram of Nanoscale Alloy Drops Used in Vapor−Liquid−Solid Growth of Semiconductor NanowiresACS Nano, 2010
- Coronary Heart Disease and Body Fat DistributionCurrent Atherosclerosis Reports, 2010
- Prevalence and Trends in Obesity Among US Adults, 1999-2008JAMA, 2010
- Standards of Medical Care in Diabetes—2010Diabetes Care, 2010
- Annual Medical Spending Attributable To Obesity: Payer-And Service-Specific EstimatesHealth Affairs, 2009
- Obesity status and sick leave: a systematic reviewObesity Reviews, 2008
- Indirect costs of obesity: a review of the current literatureObesity Reviews, 2008
- Health-economic burden of obesity in EuropeEuropean Journal of Epidemiology, 2008
- Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studiesThe Lancet, 2008
- Attempting to lose weight: Specific practices among U.S. adultsAmerican Journal of Preventive Medicine, 2004