Synthesis of Aldehydo-sugar Derivatives of Pyrazoloquinoline as Inhibitors of Herpes Simplex Virus Type 1 Replication
Open Access
- 1 February 2004
- journal article
- research article
- Published by Informa UK Limited in Journal of Enzyme Inhibition and Medicinal Chemistry
- Vol. 19 (1), 33-38
- https://doi.org/10.1080/14756360310001650219
Abstract
Synthesis of a novel series of structurally related pyrazoloquinoline nucleosides is described. All the newly synthesized compounds were examined for their in vitro antiviral activity against herpes simplex type-1 as shown by two different bioassays, namely; crystal violet staining or the MTS tetrazolium dye measurement. The acute toxicity (LD50) values of the biologically active compounds were determined.Keywords
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