Involvement of Polycomb‐group genes in establishing HoxD temporal colinearity
- 14 September 2007
- Vol. 45 (9), 570-576
- https://doi.org/10.1002/dvg.20326
Abstract
Temporal colinearity in mouse HoxD is dependent on repressive activity of sequences within the 5′ end of the complex. We show that a 5-kb DNA fragment from this region represses transgenes when combined in mouse as well as in Drosophila melanogaster. Moreover, repressive activity in Drosophila depends on some members of the Polycomb-group (PcG) genes, for example, extra sex combs. We also showed direct association of these factors with the repressive fragment, both in transgenic flies and in the context of the native mouse HoxD complex. These results suggest that the global repressive region of the HoxD complex functions in two very different species and that some PcG genes are involved in establishing the early repressive state of the HoxD complex, thus contributing to temporal colinearity. genesis 45:570–576, 2007.Keywords
This publication has 30 references indexed in Scilit:
- Evx2-Hoxd13 Intergenic Region Restricts Enhancer Association to Hoxd13 PromoterPLOS ONE, 2007
- Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27Genes & Development, 2003
- Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomainsGenes & Development, 2003
- Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste proteinGenes & Development, 2002
- Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor ComplexCell, 2002
- Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb SitesCell, 2002
- The Polycomb-Group GeneEzh2 Is Required for Early Mouse DevelopmentMolecular and Cellular Biology, 2001
- Segmental regulation of Hoxb-3 by kreislerNature, 1997
- Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex.Genes & Development, 1996
- Hox and HOM: Homologous gene clusters in insects and vertebratesCell, 1989