PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility
Open Access
- 3 January 2008
- journal article
- review article
- Published by Hindawi Limited in PPAR Research
- Vol. 2008, 1-19
- https://doi.org/10.1155/2008/243791
Abstract
Peroxisome proliferator-activated receptor gamma (PPARG) regulates cellular functions such as adipogenesis and immune cell activation. However, new information has indicated additional roles of PPARG directing the cyclic changes that occur within ovarian tissue of female mammals, including those that facilitate the release of oocytes each estrous cycle. In addition to ovarian PPARG expression and function, many PPARG actions within adipocytes and macrophages have additional direct and indirect implications for ovarian function and female fertility. This encompasses the regulation of lipid uptake and transport, insulin sensitivity, glucose metabolism, and the regulation of inflammatory mediator synthesis and release. This review discusses the developing links between PPARG activity and female reproductive function, and highlights several mechanisms that may facilitate such a relationship.Keywords
This publication has 150 references indexed in Scilit:
- Genetic variants in peroxisome proliferator-activated receptor gamma influence insulin resistance and testosterone levels in normal women, but not those with polycystic ovary syndromeFertility and Sterility, 2007
- Regulation of PPARγ transcriptional activity in 3T3-L1 adipocytesBiochemical and Biophysical Research Communications, 2003
- Identification of a Novel Peroxisome Proliferator-Activated Receptor (PPAR) γ Promoter in Man and Transactivation by the Nuclear Receptor RORα1Biochemical and Biophysical Research Communications, 2001
- Insulin Sensitizer, Troglitazone, Directly Inhibits Aromatase Activity in Human Ovarian Granulosa CellsBiochemical and Biophysical Research Communications, 2000
- The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 DiabetesBiochemical and Biophysical Research Communications, 2000
- Inhibitory Effect of a Proline-to-Alanine Substitution at Codon 12 of Peroxisome Proliferator-Activated Receptor-γ 2 on Thiazolidinedione-Induced AdipogenesisBiochemical and Biophysical Research Communications, 2000
- Regulation of Gene Expression by Activation of the Peroxisome Proliferator-Activated Receptor γ with Rosiglitazone (BRL 49653) in Human AdipocytesBiochemical and Biophysical Research Communications, 1999
- Pro12Ala Missense Mutation of the Peroxisome Proliferator Activated Receptor γ and Diabetes MellitusBiochemical and Biophysical Research Communications, 1999
- Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factorCell, 1994
- Aspects Concerning the Role of Prostaglandins for Ovarian FunctionActa Obstetricia et Gynecologica Scandinavica, 1983