C-Reactive Protein in Migraine Sufferers Similar to That of Non-Migraineurs: The Reykjavik Study
- 1 December 2009
- journal article
- Published by SAGE Publications in Cephalalgia
- Vol. 29 (12), 1301-1310
- https://doi.org/10.1111/j.1468-2982.2009.01865.x
Abstract
C-reactive protein (CRP), a marker of inflammation, has been associated with cardiovascular disease. Risk of cardiovascular disease is increased in migraineurs with aura. Results from a clinical report, case-control and a cohort study suggest that CRP is elevated in migraineurs compared with non-migraineurs. We examined the proposed association in a case-control study nested within two large population-based studies. The relationship between migraine and CRP (high-sensitivity CRP) was studied in 5906 men and women aged 55.0 ± 8.5 years in the Reykjavik Study and 1345 men and women aged 27.7 ± 5.5 years from the Reykjavik Study for the Young. A modified version of the International Headache Society's criteria was used to categorize people into migraineurs (two or more symptoms) or non-migraineurs. Migraineurs with visual or sensory symptoms were further defined as having migraine with aura (MA) or without aura (MO). Multivariable-adjusted CRP levels were similar in migraineurs and nonmigraineurs for men (0.83 vs. 0.79 mg/l, P = 0.44) and for women (0.87 vs. 0.87 mg/l, P = 0.90). When further stratified by migraine aura and age, no differences were found between non-migraineurs, MO and MA among men. In women, CRP levels were borderline higher in those with MO compared with non-migraineurs and those with MA (1.01 mg/l vs. 0.81 and 0.75 mg/l, P = 0.08 and P = 0.08) in age group 19-34 years, but significantly lower in age group 60-81 years (0.52 mg/l vs. 1.07 and 1.01 mg/l, P = 0.007 and P = 0.03). CRP levels were not increased among migraine sufferers compared with non-migraineurs. Older women migraineurs without aura had lower CRP values than nonmigraineurs and migraineurs with aura.Keywords
This publication has 26 references indexed in Scilit:
- Migraine and Biomarkers of Cardiovascular Disease in WomenCephalalgia, 2007
- Long-term and short-term alcohol consumption and levels of C-reactive proteinInternational Journal of Cardiology, 2007
- Migraine and Coronary Heart Disease Mortality: A Prospective Cohort StudyCephalalgia, 2007
- Age-dependent prevalence and clinical features of migraineNeurology, 2006
- Migraine Patients have Lower Systolic but Higher Diastolic Blood Pressure Compared with Controls in a Population-Based Study of 21 537 Subjects. The Reykjavik StudyCephalalgia, 2006
- C‐Reactive Protein May Be Increased in Migraine Patients Who Present With Complex Clinical FeaturesHeadache: The Journal of Head and Face Pain, 2006
- Headache, cerebrovascular symptoms, and strokeNeurology, 2005
- Prevalence of headache in an elderly population: attack frequency, disability, and use of medicationJournal of Neurology, Neurosurgery & Psychiatry, 2001
- Acute-Phase Proteins and Other Systemic Responses to InflammationThe New England Journal of Medicine, 1999
- Chronic Paroxysmal Hemicrania (CPH): A Review of the Clinical ManifestationsHeadache: The Journal of Head and Face Pain, 1989