Multi-functional fluorescent probe for Hg2+, Cu2+ and ClO− based on a pyrimidin-4-yl phenothiazine derivative
- 22 July 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 138 (21), 6607-6616
- https://doi.org/10.1039/c3an01214j
Abstract
A multi-functional fluorescent probe based on PzDPM (10-ethyl-3,7-di(pyrimidin-4-yl)-10H-phenothiazine) for Hg2+, Cu2+ and ClO− has been synthesized and characterized. The probe comprises an electron-donating fluorophore core of 10-ethylphenothiazine and two Hg2+-specific chelating arms of pyrimidin-4-yl. The 10-ethylphenothiazine also acts as a Cu2+/ClO−-specific reactive moiety. PzDPM exhibits green fluorescence and selectively senses Hg2+/Cu2+ upon coordination/reaction in acetonitrile (MeCN), and behaves as a turn-off chemosensor or ratiometric chemodosimeter, respectively. On the other hand, PzDPM is very weakly emissive in aqueous solution but acts as an excellent turn-on chemodosimeter for ClO− in 1 : 4 (v/v) MeCN : Tris–HCl (10 mM, pH = 7.0) with a maximum fluorescent intensity increase of over 110-fold. The probe PzDPM allows the determination of Hg2+, Cu2+ and ClO− at 10−7 M levels with satisfactory selectivity.Keywords
This publication has 59 references indexed in Scilit:
- A new colorimetric and fluorescent ratiometric sensor for Hg2+ based on 4-pyren-1-yl-pyrimidineTetrahedron, 2012
- New sensing mechanisms for design of fluorescent chemosensors emerging in recent yearsChemical Society Reviews, 2011
- Synthesis and characterization of fluorene‐based oligomers and polymers incorporating N‐arylphenothiazine‐S,S‐dioxide unitsJournal of Polymer Science Part A: Polymer Chemistry, 2011
- Optical Chemosensor for Ag+, Fe3+, and Cysteine: Information Processing at Molecular LevelOrganic Letters, 2010
- Synthesis and characterization of novel poly(p‐phenylenevinylene) derivatives containing phenothiazine‐5‐oxide and phenothiazine‐5, 5‐dioxide moietiesJournal of Polymer Science Part A: Polymer Chemistry, 2007
- Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the diseaseJournal of Orthopaedic Research, 2007
- PeroxidasesChemico-Biological Interactions, 2000
- π-Conjugated Donor−Acceptor Copolymers Constituted of π-Excessive and π-Deficient Arylene Units. Optical and Electrochemical Properties in Relation to CT Structure of the PolymerJournal of the American Chemical Society, 1996
- Direct and Sequential Potentiometric Determination of Hypochlorite, Chlorite, and Chlorate Ions When Hypochlorite Ion is Present in Large ExcessAnalytical Chemistry, 1995
- Hard and Soft Acids and BasesJournal of the American Chemical Society, 1963