The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success
Open Access
- 1 January 2012
- journal article
- Published by Springer Science and Business Media LLC in Genome Biology
- Vol. 13 (11), R103
- https://doi.org/10.1186/gb-2012-13-11-r103
Abstract
Streptococcus pneumoniae, also called the pneumococcus, is a major bacterial pathogen. Since its introduction in the 1940s, penicillin has been the primary treatment for pneumococcal diseases. Penicillin resistance rapidly increased among pneumococci over the past 30 years, and one particular multidrug-resistant clone, PMEN1, became highly prevalent globally. We studied a collection of 426 pneumococci isolated between 1937 and 2007 to better understand the evolution of penicillin resistance within this species.Keywords
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