Temporally Diverse Firing Patterns in Olfactory Receptor Neurons Underlie Spatiotemporal Neural Codes for Odors
Open Access
- 10 February 2010
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 30 (6), 1994-2006
- https://doi.org/10.1523/jneurosci.5639-09.2010
Abstract
Odorants are represented as spatiotemporal patterns of spikes in neurons of the antennal lobe (AL; insects) and olfactory bulb (OB; vertebrates). These response patterns have been thought to arise primarily from interactions within the AL/OB, an idea supported, in part, by the assumption that olfactory receptor neurons (ORNs) respond to odorants with simple firing patterns. However, activating the AL directly with simple pulses of current evoked responses in AL neurons that were much less diverse, complex, and enduring than responses elicited by odorants. Similarly, models of the AL driven by simplistic inputs generated relatively simple output. How then are dynamic neural codes for odors generated? Consistent with recent results from several other species, our recordings from locust ORNs showed a great diversity of temporal structure. Furthermore, we found that, viewed as a population, many response features of ORNs were remarkably similar to those observed within the AL. Using a set of computational models constrained by our electrophysiological recordings, we found that the temporal heterogeneity of responses of ORNs critically underlies the generation of spatiotemporal odor codes in the AL. A test then performedin vivoconfirmed that, given temporally homogeneous input, the AL cannot create diverse spatiotemporal patterns on its own; however, given temporally heterogeneous input, the AL generated realistic firing patterns. Finally, given the temporally structured input provided by ORNs, we clarified several separate, additional contributions of the AL to olfactory information processing. Thus, our results demonstrate the origin and subsequent reformatting of spatiotemporal neural codes for odors.Keywords
This publication has 41 references indexed in Scilit:
- Frequency Transitions in Odor-Evoked Neural OscillationsNeuron, 2009
- Odor-Evoked Neural Oscillations in Drosophila Are Mediated by Widely Branching InterneuronsJournal of Neuroscience, 2009
- Dynamics of Input Patterns Modulate the Behavior of a Model of Olfactory Bulb FunctionJournal of Neurophysiology, 2009
- Neural Encoding of Rapidly Fluctuating OdorsNeuron, 2009
- Dynamic Ensemble Odor Coding in the Mammalian Olfactory Bulb: Sensory Information at Different TimescalesNeuron, 2008
- Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representationsNature Neuroscience, 2007
- Coding of Odors by a Receptor RepertoireCell, 2006
- Transient Dynamics versus Fixed Points in Odor Representations by Locust Antennal Lobe Projection NeuronsNeuron, 2005
- Simple model of spiking neuronsIEEE Transactions on Neural Networks, 2003
- Olfactory network dynamics and the coding of multidimensional signalsNature Reviews Neuroscience, 2002