Immunohistochemical study of p185 HER2 and DF3 in primary breast cancer and correlation with CA-15-3 serum tumor marker
- 1 January 2002
- journal article
- research article
- Published by BMJ in International Journal of Gynecologic Cancer
- Vol. 12 (1), 74-79
- https://doi.org/10.1046/j.1525-1438.2002.01073.x
Abstract
Dimas C, Frangos-Plemenos M, Kouskouni E, Kondis-Pafitis A. Immunohistochemical study of p185 HER2 and DF3 in primary breast cancer and correlation with CA-15-3 serum tumor marker. Human epidermal growth factor receptor 2 (p185 HER2) oncoprotein immunohistochemical expression and DF3 antigen distribution were evaluated in 129 patients with primary breast cancer. p185 HER2 overexpession was positively correlated with the degree of differentiation, metastatic disease, progesterone receptors, and cytoplasmic distribution of DF3 antigen. p185 HER2 overexpression had prognostic significance for the disease-free interval.Keywords
This publication has 23 references indexed in Scilit:
- Role of HER2 gene overexpression in breast carcinomaJournal of Cellular Physiology, 2000
- The HER‐2/ neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for TherapyThe International Journal of Cell Cloning, 1998
- A novel splice variant ofHER2 with increased transformation activityMolecular Carcinogenesis, 1998
- Differential Expression of Alternatively Spliced c-erbB-2 mRNA in Primary Tumors, Lymph Node Metastases, and Bone Marrow Micrometastases from Breast Cancer PatientsBiochemical and Biophysical Research Communications, 1998
- The Multi-epitope Approach for Immunotherapy for Cancer: Identification of Several CTL Epitopes from Various Tumor-Associated Antigens Expressed on Solid Epithelial TumorsHuman Immunology, 1998
- Correlations between c-erbβ-2 Oncogene Amplification and the Expression of Its mRNA and Protein in Human Breast CarcinomasOncology, 1992
- Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian CancerScience, 1989
- Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu OncogeneScience, 1987
- Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast TumorsHybridoma, 1984
- Histological Grading and Prognosis in Breast CancerBritish Journal of Cancer, 1957