Peroxisome proliferator‐activated receptor δ controls muscle development and oxydative capability
Open Access
- 2 October 2003
- journal article
- fj express-summary
- Published by Wiley in The FASEB Journal
- Vol. 17 (15), 2299-2301
- https://doi.org/10.1096/fj.03-0269fje
Abstract
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors exerting several functions in development and metabolism. The physiological functions of PPARδ remain elusive. By using a CRE-Lox recombination approach, we generated an animal model for muscle-specific PPARδ overexpression to investigate the role of PPARδ in this tissue. Muscle- specific PPARδ overexpression results in a profound change in fiber composition due to hyperplasia and/or shift to more oxidative fiber and, as a consequence, leads to the increase of both enzymatic activities and genes implicated in oxidative metabolism. These changes in muscle are accompanied by a reduction of body fat mass, mainly due to a large reduction of adipose cell size. Furthermore, we demonstrate that endurance exercise promotes an accumulation of PPARδ protein in muscle of wild-type animals. Collectively, these results suggest that PPARδ plays an important role in muscle development and adaptive response to environmental changes, such as training exercise. They strongly support the idea that activation of PPARδ could be beneficial in prevention of metabolic disorders, such as obesity or type 2 diabetes.Keywords
Funding Information
- Institut National de la Santé et de la Recherche Médicale (Inserm U470)
This publication has 37 references indexed in Scilit:
- Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibresNature, 2002
- Regulation of Mitochondrial Biogenesis in Skeletal Muscle by CaMKScience, 2002
- Critical roles of PPARβ/δ in keratinocyte response to inflammationJournal of Bone and Joint Surgery, 2001
- Alterations of Peroxisome Proliferator-activated Receptor δ Activity Affect Fatty Acid-controlled Adipose DifferentiationPublished by Elsevier BV ,2000
- Peroxisome-proliferator-activated receptor δ mediates the effects of long-chain fatty acids on post-confluent cell proliferationBiochemical Journal, 2000
- Activation of PPARδ alters lipid metabolism in db/db miceFEBS Letters, 2000
- Inducible Gene Targeting in Mice Using the Cre/loxSystemMethods, 1998
- Regulation of skeletal muscle mass in mice by a new TGF-p superfamily memberNature, 1997
- Activation of Gene Transcription by Prostacyclin Analogues is Mediated by the Peroxisome‐Proliferators‐Activated Receptor (PPAR)JBIC Journal of Biological Inorganic Chemistry, 1996
- Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in PreadipocytesPublished by Elsevier BV ,1995