Treatment of Ethylene Glycol Poisoning with Intravenous 4-Methylpyrazole
- 14 July 1988
- journal article
- case report
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 319 (2), 97-100
- https://doi.org/10.1056/nejm198807143190206
Abstract
THE toxic effects of ethylene glycol result from its metabolic conversion by alcohol dehydrogenase into glycolic acid — a process that causes metabolic acidosis. Glycolate is then metabolized to oxalate, the apparent cause of the renal toxicity of ethylene glycol. Ethanol and methanol are also metabolized by alcohol dehydrogenase, and it is the formaldehyde and formic acid produced through this pathway that cause the toxic effects of methanol. The activity of alcohol dehydrogenase is markedly inhibited by 4-methylpyrazole in vitro1 2 3 4 and in vivo in both animals5 and humans.6 7 8 9 10 11 In studies in animals, 4-methylpyrazole has been shown to reduce or eliminate . . .Keywords
This publication has 29 references indexed in Scilit:
- The Disulfiram (Antabuse)‐Alcohol Reaction in Male Alcoholics: Its Efficient Management by 4‐MethylpyrazoleAlcohol: Clinical and Experimental Research, 1981
- Pyrazoles as inhibitors of alcohol oxidation and as important tools in alcohol research: An approach to therapy against methanol poisoningProceedings of the National Academy of Sciences of the United States of America, 1979
- Effect of 4-Methylpyrazole on ethanol elimination rate and hepatic redox changes in alcoholics with adequate or inadequate nutrition and in nonalcoholic controlsMetabolism, 1978
- Ethanol‐induced hypoglycaemia in man: its suppression by the alcohol dehydrogenase inhibitor 4‐methylpyrazoleEuropean Journal of Clinical Investigation, 1977
- Human liver alcohol dehydrogenase—inhibition of methanol activity by pyrazole, 4-methylpyrazole, 4-hydroxymethylpyrazole and 4-carboxypyrazoleBiochemical Pharmacology, 1975
- Inhibition of monkey liver alcohol dehydrogenase by 4-methylpyrazoleBiochemical Medicine, 1975
- The combustion of triolein-1-14C and its inhibition by alcohol in manLife Sciences, 1973
- Inhibitory effect on ethanol oxidation in man after administration of 4-methylpyrazoleLife Sciences, 1970
- Human Liver Alcohol Dehydrogenase: Inhibition by Pyrazole and Pyrazole Analogs.Acta Chemica Scandinavica, 1969
- On the Effects of Some Heterocyclic Compounds on the Enzymic Activity of Liver Alcohol Dehydrogenase.Acta Chemica Scandinavica, 1969