In Vivo Competition Between a Metallothionein Regulatory Element and the SV40 Enhancer
- 4 April 1986
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 232 (4746), 76-80
- https://doi.org/10.1126/science.3006253
Abstract
The human metallothionein-IIA (hMT-IIA) gene contains an enhancer element within its 5' regulatory region. This enhancer element can compete with the SV40 enhancer for one or more cellular factors in vivo. The competition between the two elements is modulated by cadmium, an inducer of hMT-IIA transcription. The data presented are consistent with a model in which heavy metal ions control the ability of the hMT-IIA enhancer to bind a positive factor, leading to increased transcription. The same factor is required for maximal activity of the SV40 enhancer, which suggests that viruses utilize factors that have a normal role in cellular gene expression to control their own genes.Keywords
This publication has 47 references indexed in Scilit:
- Competition for cellular factors that activate metallothionein gene transcriptionNature, 1984
- Specific interaction between enhancer-containing molecules and cellular componentsCell, 1984
- Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5′-flanking DNACell, 1984
- The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer elementCell, 1983
- Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequencesNature, 1983
- T antigen repression of SV40 early transcription from two promotersCell, 1981
- Expression of a β-globin gene is enhanced by remote SV40 DNA sequencesCell, 1981
- Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control regionCell, 1981
- SV40 gene expression is modulated by the cooperative binding of T antigen to DNACell, 1981
- In vivo sequence requirements of the SV40 early promoter regionNature, 1981