Metabolic syndrome and risk of incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study
Open Access
- 1 January 2008
- journal article
- Published by Springer Science and Business Media LLC in Cardiovascular Diabetology
- Vol. 7 (1), 35-8
- https://doi.org/10.1186/1475-2840-7-35
Abstract
BACKGROUND: Several aspects concerning the relationship between the metabolic syndrome and incident diabetes are incompletely understood including the magnitude of the risk estimate, potential gender differences in the associations between the metabolic syndrome and incident diabetes, the associations between the components of the metabolic syndrome and incident diabetes, and whether the metabolic syndrome provides additional prediction beyond its components. To shed light on these issues, we examined the prospective association between the metabolic syndrome defined by the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) and diabetes. METHODS: We used data for 2796 men and women aged 35–65 years from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study followed for an average of 6.9 years. This analysis employed a case-cohort design that included 697 participants who developed diabetes and 2099 participants who did not. Incident diabetes was identified on the basis of self-reports and verified by contacting the patient's attending physician. RESULTS: The adjusted hazard ratio for the NCEP definition was 4.62 (95% confidence interval [CI]: 3.90–5.48) and that for the IDF definition was 4.59 (95% CI: 3.84–5.50). The adjusted hazard ratios for the NCEP but not IDF definition were higher for women than men. When participants who had no cardiometabolic abnormalities were used as the reference group for the NCEP definition, the adjusted hazard ratio for having 3 or more abnormalities increased to 22.50 (95% CI: 11.21–45.19). Of the five components, abdominal obesity and hyperglycemia were most strongly associated with incident diabetes. CONCLUSION: In this study population, both definitions of the metabolic syndrome provided similar estimates of relative risk for incident diabetes. The increase in risk for participants with the metabolic syndrome according to the NCEP definition was very large when contrasted with the risk among those who had no cardiometabolic abnormalities.Keywords
This publication has 23 references indexed in Scilit:
- The metabolic syndrome as a tool for predicting future diabetes: the AusDiab studyJournal of Internal Medicine, 2008
- The metabolic syndrome as a predictor of incident diabetes mellitus in MauritiusDiabetic Medicine, 2007
- Development of Diabetes in Chinese With the Metabolic SyndromeDiabetes Care, 2007
- How well does the metabolic syndrome defined by five definitions predict incident diabetes and incident coronary heart disease in a Chinese population?Atherosclerosis, 2007
- Impact of Insulin Resistance on Risk of Type 2 Diabetes and Cardiovascular Disease in People With Metabolic SyndromeDiabetes Care, 2007
- The National Cholesterol Education Program–Adult Treatment Panel III, International Diabetes Federation, and World Health Organization Definitions of the Metabolic Syndrome as Predictors of Incident Cardiovascular Disease and DiabetesDiabetes Care, 2007
- Metabolic syndrome—a new world‐wide definition. A Consensus Statement from the International Diabetes FederationDiabetic Medicine, 2006
- Prediction of Type 2 Diabetes Mellitus With Alternative Definitions of the Metabolic SyndromeCirculation, 2005
- The Metabolic Syndrome: Time for a Critical AppraisalDiabetes Care, 2005
- Risks for All-Cause Mortality, Cardiovascular Disease, and Diabetes Associated With the Metabolic SyndromeDiabetes Care, 2005