Mild Cognitive Impairment:An Overview
- 1 January 2008
- journal article
- review article
- Published by Cambridge University Press (CUP) in CNS Spectrums
- Vol. 13 (1), 45-53
- https://doi.org/10.1017/s1092852900016151
Abstract
Mild cognitive impairment (MCI) refers to the transitional state between the cognitive changes of normal aging and very early dementia. MCI has generated a great deal of research from both clinical and research perspectives. Several population- and community-based studies have documented an accelerated rate of progression to dementia and Alzheimer's disease in individuals diagnosed with MCI. Clinical subtypes of MCI have been proposed to broaden the concept and include prodromal forms of a variety of dementias. An algorithm is presented to assist the clinician in identifying subjects and subclassifying them into the various types of MCI. Progression factors, including genetic, neuroimaging, biomarker, and clinical characteristics, are discussed. Neuropathological studies indicating an intermediate state between normal aging and early dementia in subjects with MCI are presented. The recently completed clinical trials as well as neuropsychological and nutritional interventions are discussed. Finally, the clinical utility of MCI, and directions for future research are proposed.Keywords
This publication has 51 references indexed in Scilit:
- Differential Cross-Sectional and Longitudinal Impact of APOE Genotype on Hippocampal Volumes in Nondemented Older AdultsDementia and Geriatric Cognitive Disorders, 2007
- Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up studyThe Lancet Neurology, 2006
- The proteomics of positron emission tomographyAnnals of Neurology, 2004
- Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐BAnnals of Neurology, 2004
- Mild cognitive impairment clinical trialsNature Reviews Drug Discovery, 2003
- Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance imagesThe Lancet, 2001
- Aging-Associated Cognitive DeclineInternational Psychogeriatrics, 1994
- Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience, 1993
- Psychotic symptoms in Alzheimer's diseaseInternational Journal of Geriatric Psychiatry, 1991
- Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work groupDevelopmental Neuropsychology, 1986