Colchicine-associated Ring Mitosis in Liver Biopsy and Their Clinical Implications
- 1 October 2008
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Clinical Gastroenterology
- Vol. 42 (9), 1060-1062
- https://doi.org/10.1097/mcg.0b013e31803815b4
Abstract
Colchicine is an alkaloid with antimitotic activity used to treat a variety of medical conditions. Colchicine toxicity can result in multiorgan failure and death. In recent years, the histopathologic features of colchicine toxicity in various organs that is, gastrointestinal tract, kidneys, salivary glands, muscle, and skin have been described. However, the histopathologic manifestations of colchicine in the liver have not been reported. We present the case of a 54-year-old man with transfusion acquired chronic hepatitis C and longstanding gout managed with colchicine. A liver biopsy performed showed changes consistent with chronic hepatitis C along with many scattered mitoses arrested in metaphase in the hepatocytes that have been referred to as “ring” mitoses. The current liver biopsy was compared with the biopsy from 7 years ago, which appeared similar, however, ring mitoses were absent. Ring mitosis have been associated with colchicine-mediated tissue injury in various other sites, and their presence is felt to represent colchicine-induced liver injury in this case.Keywords
This publication has 24 references indexed in Scilit:
- Colchicine ToxicityThe American Journal of Surgical Pathology, 2001
- Colchicine in dermatologyJournal of the American Academy of Dermatology, 1998
- Colchicine: 1998 updateSeminars in Arthritis and Rheumatism, 1998
- An Update on Terminology and ReportingThe American Journal of Surgical Pathology, 1995
- Kinetic Stabilization of Microtubule Dynamics at Steady State in Vitro by Substoichiometric Concentrations of Tubulin-Colchicine ComplexBiochemistry, 1995
- Fatal colchicine toxicityAmerican Journal Of Medicine, 1989
- Colchicine in Acute GoutJAMA, 1987
- Colchicine overdose: Report of two cases and review of the literatureAnnals of Emergency Medicine, 1981
- Fatal colchicine poisoning in a boy with familial Mediterranean feverThe American Journal of the Medical Sciences, 1979
- Massive colchicine overdose: a report on the toxicityThe American Journal of the Medical Sciences, 1976