Dishonorable Discharge: The Oncogenic Roles of Cleaved E-Cadherin Fragments
Open Access
- 14 June 2012
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 72 (12), 2917-2923
- https://doi.org/10.1158/0008-5472.can-11-3498
Abstract
Strong cell–cell interactions represent a major barrier against cancer cell mobility, and loss of intercellular adhesion by E-cadherin is a fundamental change that occurs during the progression of cancer to invasive disease. However, some aggressive carcinomas retain characteristics of differentiated epithelial cells, including E-cadherin expression. Emerging evidence indicates that proteolysis of E-cadherin generates fragments that promote tumor growth, survival, and motility, suggesting that E-cadherin cleavage converts this tumor suppressor into an oncogenic factor. In this review we discuss the emerging roles of cleaved E-cadherin fragments as modulators of cancer progression, and explore the translational and clinical implications of this research. Cancer Res; 72(12); 2917–23. ©2012 AACR.Keywords
This publication has 44 references indexed in Scilit:
- Metastatic Progression of Prostate Cancer and E-Cadherin: Regulation by Zeb1 and Src Family KinasesThe American Journal of Pathology, 2011
- Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT‐like phenotype change and MMP‐9‐mediated degradation of E‐cadherinJournal of Cellular Biochemistry, 2011
- Misregulated E-Cadherin Expression Associated with an Aggressive Brain Tumor PhenotypePLOS ONE, 2010
- Mechanisms of Motility in Metastasizing CellsMolecular Cancer Research, 2010
- The Ectodomain Shedding of E-cadherin by ADAM15 Supports ErbB Receptor ActivationPublished by Elsevier BV ,2008
- A Role for the Cleaved Cytoplasmic Domain of E-cadherin in the NucleusPublished by Elsevier BV ,2008
- Tumor Response to Combination Celecoxib and Erlotinib Therapy in Non-small Cell Lung Cancer Is Associated with a Low Baseline Matrix Metalloproteinase-9 and a Decline in Serum-Soluble E-CadherinJournal of Thoracic Oncology, 2008
- Soluble cadherins as cancer biomarkersClinical & Experimental Metastasis, 2007
- Dominant-negative E-cadherin inhibits the invasiveness of inflammatory breast cancer cells in vitroZeitschrift für Krebsforschung und Klinische Onkologie, 2006
- Wnt signalling in stem cells and cancerNature, 2005