The Blood-Brain Barrier
- 7 July 2016
- journal article
- review article
- Published by SAGE Publications in The Neuroscientist
- Vol. 23 (2), 124-136
- https://doi.org/10.1177/1073858416639005
Abstract
Sleep and its disorders are known to affect the functions of essential organs and systems in the body. However, very little is known about how the blood-brain barrier (BBB) is regulated. A few years ago, we launched a project to determine the impact of sleep fragmentation and chronic sleep restriction on BBB functions, including permeability to fluorescent tracers, tight junction protein expression and distribution, glucose and other solute transporter activities, and mediation of cellular mechanisms. Recent publications and relevant literature allow us to summarize here the sleep-BBB interactions in five sections: (1) the structural basis enabling the BBB to serve as a huge regulatory interface; (2) BBB transport and permeation of substances participating in sleep-wake regulation; (3) the circadian rhythm of BBB function; (4) the effect of experimental sleep disruption maneuvers on BBB activities, including regional heterogeneity, possible threshold effect, and reversibility; and (5) implications of sleep disruption-induced BBB dysfunction in neurodegeneration and CNS autoimmune diseases. After reading the review, the general audience should be convinced that the BBB is an important mediating interface for sleep-wake regulation and a crucial relay station of mind-body crosstalk. The pharmaceutical industry should take into consideration that sleep disruption alters the pharmacokinetics of BBB permeation and CNS drug delivery, being attentive to the chrono timing and activation of co-transporters in subjects with sleep disorders.Keywords
This publication has 101 references indexed in Scilit:
- Mechanisms of Glutamate Efflux at the Blood—Brain Barrier: Involvement of Glial CellsJournal of Cerebral Blood Flow & Metabolism, 2011
- Purinergic mechanisms in gliovascular couplingSeminars in Cell & Developmental Biology, 2011
- Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3Journal of Cerebral Blood Flow & Metabolism, 2011
- Wake promoting effects of cocaine and amphetamine-regulated transcript (CART)Neuropeptides, 2010
- Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake CycleScience, 2009
- Tripartite synapses: Roles for astrocytic purines in the control of synaptic physiology and behaviorNeuropharmacology, 2009
- Neuropeptide Y-deficient mice show altered circadian response to simulated natural photoperiodBrain Research, 2008
- Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic miceAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
- Urocortin and the brainProgress in Neurobiology, 2008
- Adipokines and the blood-brain barrierPeptides, 2007