Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach

Abstract

Immunoreactive-somatostatin (ir-somatostatin) concentrations of the gastric mucosa and gastric juice withHelicobacter pylori infection were measured in the human stomach. One hundred seventy-one patients (106 males, 65 females;, mean age, 52.0; range, 19–84 years) were registered. Gastric juice and mucosa were obtained with the usual endoscopy procedure. Somatostatin concentration was measured by radioimmunoassay. The irsomatostatin concentrations in theH. pylori-negative group were significantly higher than in the positive group gastric mucosa, whereas its levels in gastric juice tended to decrease withH. pylori infection. There was an inverse correlation between luminal ammonia levels and ir-somatostatin concentrations of the gastric mucosa. On the other hand, ir-somatostatin concentrations of the gastric mucosa significantly decreased with chronic and active inflammatory change. This decrease was not correlated with the grade of active inflammation, which was in close relation, toH. pylori infection, but with the grade of chronic inflammation. These results indicate thatH. pylori may reduce ir-somatostatin concentrations of the human stomach and that its effect is partly mediated via luminal ammonia produced byH. pylori.