Biliary and Urinary Excretion of Metals in Humans
- 1 October 1986
- journal article
- research article
- Published by Taylor & Francis Ltd in Archives of environmental health
- Vol. 41 (5), 324-330
- https://doi.org/10.1080/00039896.1986.9936705
Abstract
Fifteen metals (lead, cadmium, arsenic, inorganic mercury, organic mercury, iron, manganese, magnesium, chromium, zinc, copper, nickel, cobalt, tin, and aluminum) were determined in the hepatic bile and urine collected simultaneously from three Japanese individuals (2 males, 1 female). The presence of these metals was classified as follows: (1) hepatic biliary concentrations were higher than urinary concentrations (lead, arsenic, and iron); (2) urinary concentrations were higher than hepatic biliary concentrations (cadmium, inorganic mercury, tin, cobalt, magnesium, chromium, copper, zinc, and nickel); (3) hepatic biliary concentrations were almost equal to urinary concentrations (manganese and organic mercury); and (4) relationship between hepatic biliary and urinary concentrations changed occasionally (aluminum). Eight essential metals (iron, manganese, magnesium, zinc, chromium, copper, nickel, and cobalt) were detected at considerable concentrations in hepatic bile. Accounting for the daily flow volume of hepatic bile and the reabsorption of these metals, the supplementation of these metals should occur during treatment of diseases accompanied by loss of hepatic bile.Keywords
This publication has 29 references indexed in Scilit:
- ARSENIC TOXICITY IN CATTLEAnnals of the New York Academy of Sciences, 2006
- Biliary excretion of silver in the rat, rabbit, and dogToxicology and Applied Pharmacology, 1979
- Biliary excretion of cadmium in the rat, rabbit, and dogToxicology and Applied Pharmacology, 1977
- Biliary excretion of lead in rats rabbits, and dogs*1Toxicology and Applied Pharmacology, 1974
- Biliary excretion of manganese in rats, rabbits, and dogs*1Toxicology and Applied Pharmacology, 1974
- Biliary excretion of arsenic in rats, rabbits, and dogs*1Toxicology and Applied Pharmacology, 1974
- Chemical Methylation of Inorganic Mercury with Methylcobalamin, a Vitamin B 12 AnalogScience, 1971
- Selective atomic-absorption determination of inorganic mercury and methylmercury in undigested biological samplesThe Analyst, 1971
- Observation on Pancreatic Function in Eight Patients with Controlled Pancreatic FistulasAnnals of Surgery, 1964
- PHYSIOLOGIC OBSERVATIONS ON PATIENTS WITH EXTERNAL PANCREATIC FISTULAAnnals of Surgery, 1944