Targeting Lymphatic Metastasis

Abstract
Oncologists have long debated the part played by the lymphatic system of cancer patients in tumor metastasis. In a Perspective, Gershenwald and Fidler discuss new findings ( Padera et al.) showing that the lymphatic vessels surrounding tumors contribute to lymphatic metastasis. The authors propose that one therapeutic approach to preventing lymphatic metastasis is to block VEGF-C, a lymphangiogenic factor.