Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma
- 1 October 1994
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 371 (6499), 674-680
- https://doi.org/10.1038/371674a0
Abstract
Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.Keywords
This publication has 32 references indexed in Scilit:
- Requirement of Vascular Integrin α v β 3 for AngiogenesisScience, 1994
- Integrins: Versatility, modulation, and signaling in cell adhesionCell, 1992
- Human immunodeficiency virus (HIV) transcripts identified in HIV-related psoriasis and Kaposi's sarcoma lesions.JCI Insight, 1991
- Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.The Journal of cell biology, 1989
- THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINSAnnual Review of Biochemistry, 1989
- The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic miceNature, 1988
- Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.The Journal of cell biology, 1988
- Kaposiʼs Sarcoma in AIDSThe American Journal of Dermatopathology, 1987
- Angiogenic FactorsScience, 1987
- Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDSScience, 1984