Platelet-Rich Plasma: Underlying Biology and Clinical Correlates
- 2 September 2013
- journal article
- review article
- Published by Informa UK Limited in Regenerative Medicine
- Vol. 8 (5), 645-658
- https://doi.org/10.2217/rme.13.59
Abstract
Platelet-rich plasma (PRP) has recently become the focus of intensive interest and discussion, in part because of the expanding understanding of platelet function. Anucleate platelets within PRP release a myriad of growth factors and cytokines while contributing to plasma coagulation and fibrin development; the latter acts as vehicle for the local delivery. The biological effects of PRP are largely attributed to the platelet secretome and plasma signaling proteins. Clinical data suggest that PRPs may exploit different regenerative mechanisms under diverse disease conditions, including hemostasis, inflammation, angiogenesis and the synthesis of extracellular matrix. The success of PRP therapies depends on current tissue healing research and the translation of this knowledge into clinical developments.Keywords
Funding Information
- Basque Government (SAIO12-PE12BF007)
This publication has 84 references indexed in Scilit:
- Analysis of Autologous Platelet-Rich Plasma During Ascending and Transverse Aortic Arch SurgeryThe Annals of Thoracic Surgery, 2013
- Prospective Randomized Evaluation of a Collagen/Thrombin and Autologous Platelet Hemostatic Agent During Total Knee ArthroplastyThe Journal of Arthroplasty, 2012
- Effect on Blood Loss and Cost-Effectiveness of Pain Cocktails, Platelet-Rich Plasma, or Fibrin Sealant After Total Knee ArthroplastyThe Journal of Arthroplasty, 2012
- Platelet-rich Plasma Does Not Reduce Blood Loss or Pain or Improve Range of Motion After TKAClinical Orthopaedics & Related Research, 2012
- Use of autologous platelet-rich clots for the prevention of local injury bleeding in patients with severe inherited mucocutaneous bleeding disordersHaemophilia, 2011
- Tendon healing and platelet-rich plasma therapiesExpert Opinion on Biological Therapy, 2010
- Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)Trends in Biotechnology, 2009
- Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcersJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2007
- The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplastyInternational Orthopaedics, 2006
- Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplastyActa Anaesthesiologica Scandinavica, 2006