Activity‐Based Probes for Studying the Activity of Flavin‐Dependent Oxidases and for the Protein Target Profiling of Monoamine Oxidase Inhibitors
Open Access
- 11 June 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 51 (28), 7035-7040
- https://doi.org/10.1002/anie.201201955
Abstract
High profile: New activity‐based protein profiling (ABPP) probes have been designed that target exclusively monoamine oxidases A and B within living cells (see picture; FAD=flavin adenine dinucleotide, FMN=flavin monodinucleotide). With these probes it could be shown that the MAO inhibitor deprenyl, which is in clinical use against Parkinson's disease, shows unique protein specificity despite its covalent mechanism of action.Keywords
This publication has 79 references indexed in Scilit:
- Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1ACS Chemical Biology, 2011
- Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injuryBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
- Topological Probes of Monoamine Oxidases A and B in Rat Liver Mitochondria: Inhibition by TEMPO-Substituted Pargyline Analogues and Inactivation by ProteolysisBiochemistry, 2011
- Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdBCell Chemical Biology, 2010
- Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5tCell Chemical Biology, 2010
- Using Small Molecules To Dissect Mechanisms of Microbial PathogenesisACS Chemical Biology, 2009
- A Suite of Activity-Based Probes for Human Cytochrome P450 EnzymesJournal of the American Chemical Society, 2009
- Molecular and Mechanistic Properties of the Membrane-Bound Mitochondrial Monoamine OxidasesBiochemistry, 2009
- Monoamine oxidase inactivation: From pathophysiology to therapeuticsAdvanced Drug Delivery Reviews, 2008
- The Diverse Roles of Flavin CoenzymesNature's Most Versatile ThespiansThe Journal of Organic Chemistry, 2007