Self-organizing optic-cup morphogenesis in three-dimensional culture
- 6 April 2011
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 472 (7341), 51-56
- https://doi.org/10.1038/nature09941
Abstract
Organogenesis relies on the orchestration of many cellular interactions to create the collective cell behaviours that progressively shape developing tissues. Using a three-dimensional embryonic stem cell culture system, this study successfully generated neural retinal tissues that formed a fully stratified neural retinal structure with all the major components located in their proper spatial location as seen during optic-cup development in vivo. This approach might have important implications for stem cell therapy for retinal repair.Keywords
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